GENETIC FACTORS IN RESISTANCE TO MALARIA

Malaria drug - resistance in Iran

Introduction: Malaria is a public health problem for approximately 2.4 billion people, 40% of the world’s population, particularly in the tropical and subtropical countries. Countries in Asia, and Latin America, the islands of the South, West, and central pacific ocean are all affected. Drug resistance is the greatest challenge in combating against malaria. Drug resistance in malaria is now w...

Host genetic factors in malaria

It is estimated that each 25%-30% in the variability in the incidence of malaria can be attributed to genetic and environmental factors, respectively. In various study designs on the different types of manifestation of Plasmodium falciparum infection, associations between genetic polymorphisms and malaria are examined. The selection of polymorphisms under study follows hypotheses on the role of...

Measuring resistance to malaria.

Identifying permethrin resistance loci in malaria vectors by genetic mapping

Identification of the major loci responsible for insecticide resistance in malaria vectors would aid the development and implementation of effective resistance management strategies, which are urgently needed to tackle the growing threat posed by resistance to the limited insecticides available for malaria control. Genome-wide association studies in the major malaria vector, Anopheles gambiae, ...

Genetic structure and evolved malaria resistance in Hawaiian honeycreepers.

Infectious diseases now threaten wildlife populations worldwide but population recovery following local extinction has rarely been observed. In such a case, do resistant individuals recolonize from a central remnant population, or do they spread from small, perhaps overlooked, populations of resistant individuals? Introduced avian malaria (Plasmodium relictum) has devastated low-elevation popul...